Samarium (153Sm) lexidronam

Samarium (153Sm) lexidronam
Systematic (IUPAC) name
Pentasodium samarium (153Sm) N,N,N',N'-tetrakis(phosphonatomethyl)ethane-1,2-diamine
Clinical data
Pregnancy cat. D(US)
Legal status Prescription only
Routes Intravenous
Pharmacokinetic data
Bioavailability N/A
Identifiers
ATC code V10BX02
PubChem CID 9810246
ChEMBL CHEMBL1201796
Chemical data
Formula C6H12N2Na5O12P4153Sm
Mol. mass 695.93 g/mol
SMILES eMolecules & PubChem

Samarium (153Sm) lexidronam (chemical name Samarium-153-ethylene diamine tetramethylene phosphonate, abbreviated Samarium-153 EDTMP, trade name Quadramet) is a complex of a radioisotope of the lanthanide element samarium with the chelator EDTMP. It is used to treat pain when cancer has spread to the bone.[1][2]

It is injected into a vein and distributes throughout the body. It homes in on areas where cancer has invaded the bone. Once there, the radioisotope emits beta particles (electrons) which kill the nearby cancer cells. Pain begins to improve in the first week for most people and the effects can last several months. It is commonly used in lung cancer, prostate cancer, breast cancer, and osteosarcoma.

Side effects result from radiation to the bone marrow and include thrombocytopenia and leukopenia.

References